School of Information Science and Technology was established in January 2019, on the basis of former School of Electronic Information and School of Computer Science and Technology. There are 9 undergraduate programs including electronic information engineering, telecommunication engineering, electronic science and technology, integrated circuit design and integrated system, computer science and technology, software engineering, network engineering, internet of things engineering, data science and big data technology. There are master program in information and communication engineering, professional master program in electronic information, and doctoral program in information and communication engineering. There are now 4 first-class disciplines including information and communication engineering, electronic science and technology, computer science and technology, and software engineering in the school. The school has  Key Laboratory of Special Integrated Circuit Design of Jiangsu Province, Tongke School of Microelectronics, Aliyun School of Big Data, Research Center for Information Science and Technology. It also has six departments (divisions) including Information Engineering Department, Telecommunication Engineering Department, Electronic Engineering Department, Computer Science and Technology Department, Software Engineering Department, Network Engineering Department, and Experimental Center of the School, EDA Experimental Center of Nantong University, Experimental Center for Information and Communication Engineering of Nantong University and Experimental Teaching Center for Computer Application Technology.

There are now 211 teachers including 172 full-time teachers, 29 professors, 83 associate professors, 94 doctors in the school. There are 3419 full-time undergraduates and 217 master students and 25 doctor students.

ESI engineering ranked 1% among the total.

The school has Nantong Public Service Platform of Electronic Information Technology, Nantong Public Service Platform of Virtual Reality Technology, Nantong Key Laboratory of High Performance Computing and Nantong Public Service Platform for Design and Inspection of Radio Frequency Products in the School. It successively made deep industry-university-research cooperation with over 20 enterprises such as ZTT Group, Tongfu Microelectronics Co., Ltd. and Hanwha Q Cells (Qidong) Co., Ltd. The School was praised by enterprises for providing technical guidance, professional consultation and scientific research cooperation.